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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Tanshinone IIA, Doxorubicin
Phytochemical Name Tanshinone IIA (PubChem CID: 164676 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Doxorubicin
Adverse Reactions Nausea, vomiting, diarrhoea. This was inferred cold nature anticancer drug.
Recommendations Hot: Ligusticum chuam; Angelica sinensis; Zingiber officinale; Panax ginseng; Pogostemon cablin
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 200
Ref_1
Pair Name Tanshinone IIA, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression PTEN hsa5728
Down-regulation Expression AKT1 hsa207
Down-regulation Expression ABCB1 hsa5243
Down-regulation Expression ABCG2 hsa9429
Down-regulation Expression ABCC1 hsa4363
In Vitro Model MCF-7 Invasive breast carcinoma Homo sapiens (Human) CVCL_0031
MCF-7(DOX/R) Invasive breast carcinoma Homo sapiens (Human) CVCL_C4M9
In Vivo Model 2×10⁷ MCF‐7 cells were injected subcutaneously into the rightpostauricular region of each nude mouse.
Result Tan IIA could be used as a novel agent combined with Dox in breast cancer therapy.
Enhancing Drug Efficacy
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Combination Pair ID: 294
Ref_2
Pair Name Tanshinone IIA, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression CTNNB1 hsa1499
In Vitro Model MCF-7(DOX/R) Invasive breast carcinoma Homo sapiens (Human) CVCL_C4M9
Result Tan II A could be used as a potential chemosensitizer in combination with Dox for breast cancer chemotherapy.
03. Reference
No. Title Href
1 Combination of tanshinone IIA and doxorubicin possesses synergism and attenuation effects on doxorubicin in the treatment of breast cancer. Phytother Res. 2019 Jun;33(6):1658-1669. doi: 10.1002/ptr.6353. Click
2 Tanshinone II A improves the chemosensitivity of breast cancer cells to doxorubicin by inhibiting β-catenin nuclear translocation. J Biochem Mol Toxicol. 2021 Jan;35(1):e22620. doi: 10.1002/jbt.22620. Epub 2020 Sep 4. Erratum in: J Biochem Mol Toxicol. 2021 Apr;35(4):e22790. Click
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